Heidelberg Biosciences International Graduate School (HBIGS)
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Last update: 29 Nov 2024
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PhD Position: Mechanobiology of immune cells in native tissue
Are you a highly motivated, curious researcher who is captivated by immune cell biology? Are you fascinated by interdisciplinary research on the interface of biology and physics? If you're eager to explore immune cell behavior using cutting-edge technologies like microfluidics, advanced microscopy, and mechanobiology tools, this could be the PhD opportunity for you! Immune cells are highly dynamic, and mechanical forces have emerged as regulators of key immune functions. In the Vorselen Lab, we develop new biophysical technologies to tune the physical stimuli that cells receive and assess cellular forces, and combine this with high-resolution microscopy and cellular perturbations. This combination provides a detailed readout of immune cell behavior and helps us understand the regulation of immune processes by physical forces in health and disease. We primarily focus on innate immune processes and phagocytosis speficially. This project focuses on advancing cellular force-sensing technology. The goals are to precisely measure immune forces and interrogate macrophage dynamics in complex 3D environments, including in live zebrafish embryos. Your duties and responsibilities include:
- Develop a novel force sensor able to detect cellular forces with high sensitivity in vivo;
- Determine the dynamics of immune cells in native tissue through in vivo studies in zebrafish embryos,
- Delineate how immune cell dynamics are governed by physical tissue properties, such as cellular confinement;
Your qualities
The ideal candidate has the following qualities:
- A successfully completed MSc degree in physical sciences, bioengineering, biotechnology, or a related discipline;
- Strong and proven affinity with interdisciplinary research at the interface of biology and physics;
- Work experience with fluorescence microscopy, microfluidics, zebrafish and/or immune cell culture;
- Good quantitative skills;
- Proficiency in programming is a pre;
- Excellent communication skills in English (both oral and written).
We offer you
Wageningen University & Research offers excellent terms of employment . A few highlights from our Collective Labour Agreement include:
- Partially paid parental leave;
- working hours that can be discussed and arranged so that they allow for the best possible work-life balance;
- there is a strong focus on vitality and you can make use of the sports facilities available on campus for a small fee;
- a fixed December bonus of 8.3%;
- excellent pension scheme.
Do you want more information?
For more information about this position, please contact Daan Vorselen by e-mail [email protected]. For more information about the procedure, please contact Ine van’t Land, corporate recruiter by e-mail [email protected]. Do you want to apply? You can apply directly using the apply button on the vacancy page on our website which will allow us to process your personal information with your approval. This vacancy will be listed up to and including Decemer 16th, 2024 Welcome, safe, and valued Wageningen University & Research (WUR) highly values diversity and inclusion because we believe that different insights lead to innovative solutions. We create a work environment where everyone feels welcome, safe, and appreciated, regardless of background, identity, or experience. Together, we are building a culture where everyone's unique contribution adds to the success of our organization.
EMBL International PhD Programme
Unique in the world and waiting for you!
The EMBL International PhD Programme (EIPP), originally established in 1983, provides PhD students with an excellent starting platform for a successful career in science by fostering early independence and interdisciplinary research .
EMBL is dedicated to promoting excellence in the molecular life sciences throughout Europe. To achieve this goal, we inspire and train talented young scientists to become skilled and creative future leaders in academia, industry and other sectors.
The EIPP provides comprehensive interdisciplinary training, maintaining a careful balance between theory and practice, close mentoring and creative freedom, collaborative teamwork and independence. These key characteristics make the EIPP a role model , which has inspired similar programmes at research institutions throughout Europe and the world.
The enriching encounter of different nationalities, the friendly and collaborative atmosphere , and the passion for science is what unites EMBL’s diverse staff and provides the ideal setting to forge long-lasting connections and make studying at EMBL a unique formative experience.
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New PhD students admitted each year
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Application
Two recruitment rounds are organised each year across all EMBL sites. The application deadlines and all relevant information are published well in advance.
Registration for the 2025 PhD Winter Recruitment is closed
The next round of applications will open towards the end of January 2025.
Programme Overview
Explore the structure and content of the EMBL International PhD Programme.
Research at EMBL
Find out more about the cutting-edge Research Topics investigated across our different Research Units .
The complexity of current biological research questions increasingly calls for interdisciplinary approaches . To prepare our students for this challenge, the EIPP puts great emphasis on bringing together different fields of expertise: we actively encourage candidates with backgrounds in chemistry, physics, mathematics, molecular medicine, computer science or engineering to apply and work closely with biologists to answer fundamental questions in life sciences.
PHD Symposium
Since its first edition in 2000, the annual EMBL International PhD Symposium in Heidelberg developed into a well-recognized and highly appreciated scientific event.
It is always EMBL’s first year PhD students who take on the responsibility for the conceptual development and organization of the meeting. The symposia provide a great platform for networking and scientific exchange, featuring lectures by top-level scientists as well as plenty of opportunities for young researchers to present their work.
See the full list of past symposia
Upcoming symposium
Biology Outside The Box
2-4 December 2024 EMBL Heidelberg
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COMMENTS
The International Max Planck Research School for Molecules of Life (IMPRS-ML), offers fully funded PhD student positions in the areas of biochemistry, structural biology, biophysics, cell biology, systems biology and computational biology.
A PhD in Cell Biology would allow you to gain an array of laboratory skills, most notably in cell culture, which is essential to any Cell Biology project. You’ll also use classic laboratory methods such as immunoassays, chromatography, and fluorescence assays.
The International Max Planck Research School for Molecules of Life (IMPRS-ML), offers fully funded PhD student positions in the areas of biochemistry, structural biology, biophysics, cell biology, systems biology and computational biology.
The focus of the Graduate School on molecular and cellular biology takes into account that molecular and cellular biology provides the conceptual and technological foundation on which most other fields, sub-disciplines and specialized areas of life and biosciences rest - from structural biology to bioinformatics, from molecular medicine to ...
Strong and proven affinity with interdisciplinary research at the interface of biology and physics; Work experience with fluorescence microscopy, microfluidics, zebrafish and/or immune cell culture; Good quantitative skills; Proficiency in programming is a pre; Excellent communication skills in English (both oral and written).
The EMBL International PhD Programme (EIPP), originally established in 1983, provides PhD students with an excellent starting platform for a successful career in science by fostering early independence and interdisciplinary research.